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Secretin occurs as hormone produced in the S cells of the duodenum in response to low duodenum pH and fatty acids in a duodenum to stimulate the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This assists neutralize a stomachal acid typing a duodenum from the stomach.

It too inhibits acid secretion from either a abdomen by reducing gastrin release from a G cells of the abdomen.

It contains Xxvii amino acids and is homologus to glucagon.

Secretin was a foremost substance which was identified to drive a physiologic burden in the system fallowing existence transported via the blood. A term hormone was coined by Bayliss and Starling to categorise such chemical messengers.

Secretin
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